Ontology highlight
ABSTRACT:
SUBMITTER: Bennett BD
PROVIDER: S-EPMC42383 | biostudies-other | 1995 Mar
REPOSITORIES: biostudies-other
Bennett B D BD Zeigler F C FC Gu Q Q Fendly B B Goddard A D AD Gillett N N Matthews W W
Proceedings of the National Academy of Sciences of the United States of America 19950301 6
Htk is a receptor protein-tyrosine kinase that is related to the EPH subfamily of tyrosine kinases. The receptor has a wide tissue distribution including expression in several myeloid hematopoietic cell lines. Using an Htk-Fc fusion protein, a protein ligand for this receptor was expression cloned from the murine kidney mesangial cell line SV40MES 13. The Htk ligand cDNA encodes a transmembrane protein of 336 amino acids. Binding competition experiments demonstrated a Kd of 535 pM for binding of ...[more]