Transiently active Wnt/?-catenin signaling is not required but must be silenced for stem cell function during muscle regeneration.
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ABSTRACT:
SUBMITTER: Murphy MM
PROVIDER: S-EPMC4266007 | biostudies-other | 2014 Sep
REPOSITORIES: biostudies-other
Publications
Transiently active Wnt/β-catenin signaling is not required but must be silenced for stem cell function during muscle regeneration.
Murphy Malea M MM Keefe Alexandra C AC Lawson Jennifer A JA Flygare Steven D SD Yandell Mark M Kardon Gabrielle G
Stem cell reports 20140731 3
Adult muscle's exceptional capacity for regeneration is mediated by muscle stem cells, termed satellite cells. As with many stem cells, Wnt/β-catenin signaling has been proposed to be critical in satellite cells during regeneration. Using new genetic reagents, we explicitly test in vivo whether Wnt/β-catenin signaling is necessary and sufficient within satellite cells and their derivatives for regeneration. We find that signaling is transiently active in transit-amplifying myoblasts, but is not ...[more]
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