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Definition of cure in childhood acute myeloid leukemia.

ABSTRACT: A better understanding of when cure can be declared in childhood acute myeloid leukemia (AML) would reduce anxiety and improve quality of life of AML survivors. The authors determined the likelihood that patients with AML would maintain long-term remission after the completion of therapy.The cumulative risk of relapse, the time to relapse, event-free survival, and overall survival were analyzed for 604 patients with AML who were enrolled in 7 successive clinical trials divided into 3 treatment eras (1976-1991, 1991-1997, and 2002-2008).The median time to relapse did not change over time (0.93 years vs 0.76 years vs 0.8 years, respectively, for each consecutive era; P =?.22), but the risk of relapse decreased significantly (5-year cumulative incidence of relapse: 52.6% ± 3.1% vs 31.5% ± 3.9% vs 22% ± 3%, respectively, for each consecutive era; P

SUBMITTER: Rubnitz JE

PROVIDER: S-EPMC4282842 | biostudies-other | 2014 Aug

REPOSITORIES: biostudies-other

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Definition of cure in childhood acute myeloid leukemia.

Rubnitz Jeffrey E JE Inaba Hiroto H Leung Wing H WH Pounds Stanley S Cao Xueyuan X Campana Dario D Ribeiro Raul C RC Pui Ching-Hon CH

Cancer 20140502 16

<h4>Background</h4>A better understanding of when cure can be declared in childhood acute myeloid leukemia (AML) would reduce anxiety and improve quality of life of AML survivors. The authors determined the likelihood that patients with AML would maintain long-term remission after the completion of therapy.<h4>Methods</h4>The cumulative risk of relapse, the time to relapse, event-free survival, and overall survival were analyzed for 604 patients with AML who were enrolled in 7 successive clinica ...[more]

PMID: 24798038

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