Unleashing antitumor T-cell activation without ensuing autoimmunity: the case for A20-deletion in adoptive CD8(+) T-cell therapy.
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ABSTRACT: Mechanisms controlling immune reactivity prevent excessive inflammation and autoimmunity, but generally dampen antitumor activity. We recently showed that adoptively transferred antitumor CD8(+) T cells harboring a deletion of A20/Tnfaip3, a molecule controlling NF-κB activation, possessed heightened antitumor activity in vivo. The boosted immunity of A20-deleted CD8(+) T cells correlated with a heightened capacity to produce IFNγ and TNFα while expressing reduced levels of the immune checkpoint molecule PD-1.
SUBMITTER: Verdeil G
PROVIDER: S-EPMC4292241 | biostudies-other | 2014 Oct
REPOSITORIES: biostudies-other
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