Ontology highlight
ABSTRACT:
SUBMITTER: Fedorowicz MA
PROVIDER: S-EPMC4303452 | biostudies-other | 2014 Jan
REPOSITORIES: biostudies-other
Fedorowicz Maja A MA de Vries-Schneider Rosa L A RL Rüb Cornelia C Becker Dorothea D Huang Yong Y Zhou Chun C Alessi Wolken Dana M DM Voos Wolfgang W Liu Yuhui Y Przedborski Serge S
EMBO reports 20131215 1
PINK1 is a mitochondrial kinase proposed to have a role in the pathogenesis of Parkinson's disease through the regulation of mitophagy. Here, we show that the PINK1 main cleavage product, PINK152, after being generated inside mitochondria, can exit these organelles and localize to the cytosol, where it is not only destined for degradation by the proteasome but binds to Parkin. The interaction of cytosolic PINK1 with Parkin represses Parkin translocation to the mitochondria and subsequent mitopha ...[more]