Ontology highlight
ABSTRACT:
SUBMITTER: Barazzuol L
PROVIDER: S-EPMC7084677 | biostudies-literature | 2020 Mar
REPOSITORIES: biostudies-literature
Barazzuol Lucia L Giamogante Flavia F Brini Marisa M Calì Tito T
International journal of molecular sciences 20200305 5
Endoplasmic reticulum (ER)-mitochondria contact sites are critical structures for cellular function. They are implicated in a plethora of cellular processes, including Ca<sup>2+</sup> signalling and mitophagy, the selective degradation of damaged mitochondria. Phosphatase and tensin homolog (PTEN)-induced kinase (PINK) and Parkin proteins, whose mutations are associated with familial forms of Parkinson's disease, are two of the best characterized mitophagy players. They accumulate at ER-mitochon ...[more]