Weak male-driven molecular evolution in rodents.
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ABSTRACT:
SUBMITTER: Chang BH
PROVIDER: S-EPMC43042 | biostudies-other | 1994 Jan
REPOSITORIES: biostudies-other
Publications
Weak male-driven molecular evolution in rodents.
Chang B H BH Shimmin L C LC Shyue S K SK Hewett-Emmett D D Li W H WH
Proceedings of the National Academy of Sciences of the United States of America 19940101 2
In humans and rodents the male-to-female ratio of mutation rate (alpha m) has been suggested to be extremely large, so that the process of nucleotide substitution is almost completely male-driven. However, our sequence data from the last intron of the X chromosome-linked (Zfx) and Y chromosome-linked (Zfy) zinc finger protein genes suggest that alpha m is only approximately 2 in rodents with a 95% confidence interval from 1 to 3. Moreover, from published data on oogenesis and spermatogenesis we ...[more]
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