Ontology highlight
ABSTRACT:
SUBMITTER: Kaya A
PROVIDER: S-EPMC6992709 | biostudies-literature | 2020 Jan
REPOSITORIES: biostudies-literature
Kaya Alaattin A Mariotti Marco M Tyshkovskiy Alexander A Zhou Xuming X Hulke Michelle L ML Ma Siming S Gerashchenko Maxim V MV Koren Amnon A Gladyshev Vadim N VN
Nature communications 20200130 1
Alteration of normal ploidy (aneuploidy) can have a number of opposing effects, such as unbalancing protein abundances and inhibiting cell growth but also accelerating genetic diversification and rapid adaptation. The interplay of these detrimental and beneficial effects remains puzzling. Here, to understand how cells develop tolerance to aneuploidy, we subject disomic (i.e. with an extra chromosome copy) strains of yeast to long-term experimental evolution under strong selection, by forcing dis ...[more]