Ontology highlight
ABSTRACT:
SUBMITTER: Thompson RB
PROVIDER: S-EPMC4321314 | biostudies-other | 2015 Feb
REPOSITORIES: biostudies-other
Thompson Richard B RB Reffatto Valentina V Bundy Jacob G JG Kortvely Elod E Flinn Jane M JM Lanzirotti Antonio A Jones Emrys A EA McPhail David S DS Fearn Sarah S Boldt Karsten K Ueffing Marius M Ratu Savanjeet Guy Singh SG Pauleikhoff Laurenz L Bird Alan C AC Lengyel Imre I
Proceedings of the National Academy of Sciences of the United States of America 20150120 5
Accumulation of protein- and lipid-containing deposits external to the retinal pigment epithelium (RPE) is common in the aging eye, and has long been viewed as the hallmark of age-related macular degeneration (AMD). The cause for the accumulation and retention of molecules in the sub-RPE space, however, remains an enigma. Here, we present fluorescence microscopy and X-ray diffraction evidence for the formation of small (0.5-20 μm in diameter), hollow, hydroxyapatite (HAP) spherules in Bruch's me ...[more]