Ontology highlight
ABSTRACT:
SUBMITTER: Del Sal G
PROVIDER: S-EPMC43261 | biostudies-other | 1994 Mar
REPOSITORIES: biostudies-other
Del Sal G G Collavin L L Ruaro M E ME Edomi P P Saccone S S Valle G D GD Schneider C C
Proceedings of the National Academy of Sciences of the United States of America 19940301 5
We describe the isolation, growth-suppressing activity, and chromosomal localization of the human homologue of the murine growth-arrest-specific gene gas1. Overexpression of h-gas1 is able to block cell proliferation in the A549 lung carcinoma and the T24 bladder carcinoma cell lines. No effect was observed when h-gas1 was introduced into the osteosarcoma cell line SAOS-2 and into the adenovirus-type-5 transformed cell line 293. This finding is related to our previous evidence that simian virus ...[more]