Ontology highlight
ABSTRACT:
SUBMITTER: Chen H
PROVIDER: S-EPMC1915121 | biostudies-other | 1996 Jul
REPOSITORIES: biostudies-other
Chen H H Rossier C C Lalioti M D MD Lynn A A Chakravarti A A Perrin G G Antonarakis S E SE
American journal of human genetics 19960701 1
In an effort to contribute to the transcript map of human chromosome 21 and the understanding of the pathophysiology of trisomy 21, we have used exon trapping to identify fragments of chromosome 21 genes. Two trapped exons, from pools of chromosome 21-specific cosmids, showed homology to the Drosophila white (w) gene. We subsequently cloned the corresponding cDNA for a human homologue of the Drosophila w gene (hW) from human retina and fetal brain cDNA libraries. The gene belongs to the ATP-bind ...[more]