Alterations in brain leptin signalling in spite of unchanged CSF leptin levels in Alzheimer's disease.
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ABSTRACT:
SUBMITTER: Maioli S
PROVIDER: S-EPMC4326905 | biostudies-other | 2015 Feb
REPOSITORIES: biostudies-other
Publications
Alterations in brain leptin signalling in spite of unchanged CSF leptin levels in Alzheimer's disease.
Maioli Silvia S Lodeiro Maria M Merino-Serrais Paula P Falahati Farshad F Khan Wasim W Puerta Elena E Codita Alina A Rimondini Roberto R Ramirez Maria J MJ Simmons Andrew A Gil-Bea Francisco F Gil-Bea Francisco F Westman Eric E Cedazo-Minguez Angel A
Aging cell 20141202 1
Several studies support the relation between leptin and Alzheimer's disease (AD). We show that leptin levels in CSF are unchanged as subjects progress to AD. However, in AD hippocampus, leptin signalling was decreased and leptin localization was shifted, being more abundant in reactive astrocytes and less in neurons. Similar translocation of leptin was found in brains from Tg2576 and apoE4 mice. Moreover, an enhancement of leptin receptors was found in hippocampus of young Tg2576 mice and in pri ...[more]
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