Ontology highlight
ABSTRACT:
SUBMITTER: Loose M
PROVIDER: S-EPMC4334831 | biostudies-other | 2015 Jan
REPOSITORIES: biostudies-other
Loose Maria M Hudel Martina M Zimmer Klaus-Peter KP Garcia Ernesto E Hammerschmidt Sven S Lucas Rudolf R Chakraborty Trinad T Pillich Helena H
The Journal of infectious diseases 20140902 2
Microbial infections can induce aberrant responses in cellular stress pathways, leading to translational attenuation, metabolic restriction, and activation of oxidative stress, with detrimental effects on cell survival. Here we show that infection of human airway epithelial cells with Streptococcus pneumoniae leads to induction of endoplasmic reticulum (ER) and oxidative stress, activation of mitogen-associated protein kinase (MAPK) signaling pathways, and regulation of their respective target g ...[more]