Ontology highlight
ABSTRACT:
SUBMITTER: Ren C
PROVIDER: S-EPMC4336573 | biostudies-other | 2015 Feb
REPOSITORIES: biostudies-other
Ren Chunyan C Morohashi Keita K Plotnikov Alexander N AN Jakoncic Jean J Smith Steven G SG Li Jiaojie J Zeng Lei L Rodriguez Yoel Y Stojanoff Vivian V Walsh Martin M Zhou Ming-Ming MM
Chemistry & biology 20150205 2
Chromobox homolog 7 (CBX7) plays an important role in gene transcription in a wide array of cellular processes, ranging from stem cell self-renewal and differentiation to tumor progression. CBX7 functions through its N-terminal chromodomain (ChD), which recognizes trimethylated lysine 27 of histone 3 (H3K27me3), a conserved epigenetic mark that signifies gene transcriptional repression. In this study, we report the discovery of small molecules that inhibit CBX7ChD binding to H3K27me3. Our crysta ...[more]