Lentiviral transduction of dendritic cells confers protective antiviral immunity in vivo.
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ABSTRACT: Control of a viral infection in vivo requires a rapid and efficient cytotoxic-T-lymphocyte response. We demonstrate that lentivirus-mediated introduction of antigen in dendritic cells confers a protective antiviral immunity in vivo in a lymphocytic choriomeningitis virus model. Therefore, lentiviral vectors may be excellent vaccine candidates for viral infections.
SUBMITTER: Zarei S
PROVIDER: S-EPMC434082 | biostudies-other | 2004 Jul
REPOSITORIES: biostudies-other
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