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Lentiviral transduction of dendritic cells confers protective antiviral immunity in vivo.


ABSTRACT: Control of a viral infection in vivo requires a rapid and efficient cytotoxic-T-lymphocyte response. We demonstrate that lentivirus-mediated introduction of antigen in dendritic cells confers a protective antiviral immunity in vivo in a lymphocytic choriomeningitis virus model. Therefore, lentiviral vectors may be excellent vaccine candidates for viral infections.

SUBMITTER: Zarei S 

PROVIDER: S-EPMC434082 | biostudies-other | 2004 Jul

REPOSITORIES: biostudies-other

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