Ontology highlight
ABSTRACT:
SUBMITTER: Witkowski W
PROVIDER: S-EPMC4514788 | biostudies-literature | 2015
REPOSITORIES: biostudies-literature
Witkowski Wojciech W Vermeire Jolien J Landi Alessia A Naessens Evelien E Vanderstraeten Hanne H Nauwynck Hans H Favoreel Herman H Verhasselt Bruno B
PloS one 20150724 7
The function of dendritic cells (DCs) in the immune system is based on their ability to sense and present foreign antigens. Powerful tools to research DC function and to apply in cell-based immunotherapy are either silencing or overexpression of genes achieved by lentiviral transduction. To date, efficient lentiviral transduction of DCs or their monocyte derived counterparts (MDDCs) required high multiplicity of infection (MOI) or the exposure to the HIV-2/SIV protein Vpx to degrade viral restri ...[more]