Ontology highlight
ABSTRACT:
SUBMITTER: Sanulli S
PROVIDER: S-EPMC4352895 | biostudies-other | 2015 Mar
REPOSITORIES: biostudies-other
Sanulli Serena S Justin Neil N Teissandier Aurélie A Ancelin Katia K Portoso Manuela M Caron Matthieu M Michaud Audrey A Lombard Berangère B da Rocha Simao T ST Offer John J Loew Damarys D Servant Nicolas N Wassef Michel M Burlina Fabienne F Gamblin Steve J SJ Heard Edith E Margueron Raphaël R
Molecular cell 20150122 5
Polycomb Group (PcG) proteins maintain transcriptional repression throughout development, mostly by regulating chromatin structure. Polycomb Repressive Complex 2 (PRC2), a component of the Polycomb machinery, is responsible for the methylation of histone H3 lysine 27 (H3K27me2/3). Jarid2 was previously identified as a cofactor of PRC2, regulating PRC2 targeting to chromatin and its enzymatic activity. Deletion of Jarid2 leads to impaired orchestration of gene expression during cell lineage commi ...[more]