Unknown

Dataset Information

0

A new antiviral: chimeric 3TC-AZT phosphonate efficiently inhibits HIV-1 in human tissues ex vivo.


ABSTRACT: Although more-recently developed antivirals target different molecules in the HIV-1 replication cycle, nucleoside reverse transcriptase inhibitors (NRTIs) remain central for HIV-1 therapy. Here, we test the anti-HIV activity of a phosphonate chimera of two well-known NRTIs, namely AZT and 3TC. We show that this newly synthesized compound suppressed HIV-1 infection in lymphoid tissue ex vivo more efficiently than did other phosphonates of NRTIs. Moreover, the new compound was not toxic for tissue cells, thus making the chimeric phosphonate strategy a valid approach for the development of anti HIV-1 compound heterodimers.

SUBMITTER: Vanpouille C 

PROVIDER: S-EPMC4358798 | biostudies-other | 2014 Sep

REPOSITORIES: biostudies-other

altmetric image

Publications

A new antiviral: chimeric 3TC-AZT phosphonate efficiently inhibits HIV-1 in human tissues ex vivo.

Vanpouille Christophe C   Khandazhinskaya Anastasia A   Karpenko Inna I   Zicari Sonia S   Barreto-de-Souza Victor V   Frolova Svetlana S   Margolis Leonid L   Kochetkov Sergey S  

Antiviral research 20140707


Although more-recently developed antivirals target different molecules in the HIV-1 replication cycle, nucleoside reverse transcriptase inhibitors (NRTIs) remain central for HIV-1 therapy. Here, we test the anti-HIV activity of a phosphonate chimera of two well-known NRTIs, namely AZT and 3TC. We show that this newly synthesized compound suppressed HIV-1 infection in lymphoid tissue ex vivo more efficiently than did other phosphonates of NRTIs. Moreover, the new compound was not toxic for tissue  ...[more]

Similar Datasets

| S-EPMC5541768 | biostudies-literature
| S-EPMC5432875 | biostudies-literature
| S-EPMC3488859 | biostudies-literature
| S-EPMC3981911 | biostudies-literature
| S-EPMC9076641 | biostudies-literature
| S-EPMC8821821 | biostudies-literature
| S-EPMC2168974 | biostudies-literature
| S-EPMC8103695 | biostudies-literature
| S-EPMC7701360 | biostudies-literature
| S-EPMC4027223 | biostudies-literature