Ontology highlight
ABSTRACT:
SUBMITTER: Vanpouille C
PROVIDER: S-EPMC4358798 | biostudies-other | 2014 Sep
REPOSITORIES: biostudies-other
Vanpouille Christophe C Khandazhinskaya Anastasia A Karpenko Inna I Zicari Sonia S Barreto-de-Souza Victor V Frolova Svetlana S Margolis Leonid L Kochetkov Sergey S
Antiviral research 20140707
Although more-recently developed antivirals target different molecules in the HIV-1 replication cycle, nucleoside reverse transcriptase inhibitors (NRTIs) remain central for HIV-1 therapy. Here, we test the anti-HIV activity of a phosphonate chimera of two well-known NRTIs, namely AZT and 3TC. We show that this newly synthesized compound suppressed HIV-1 infection in lymphoid tissue ex vivo more efficiently than did other phosphonates of NRTIs. Moreover, the new compound was not toxic for tissue ...[more]