Ontology highlight
ABSTRACT:
SUBMITTER: Tanaka S
PROVIDER: S-EPMC43593 | biostudies-other | 1994 Apr
REPOSITORIES: biostudies-other
Tanaka S S Morishita T T Hashimoto Y Y Hattori S S Nakamura S S Shibuya M M Matuoka K K Takenawa T T Kurata T T Nagashima K K
Proceedings of the National Academy of Sciences of the United States of America 19940401 8
CRK protein, together with GRB2/ASH and Nck proteins, belongs to the adaptor-type Src homology (SH)2-containing molecules, which transduce signals from tyrosine kinases. Here another guanine nucleotide-releasing protein (GNRP), C3G, has been identified as a CRK SH3-binding protein. The nucleotide sequence of a 4.1-kb C3G cDNA contains a 3.2-kb open reading frame encoding a 121-kDa protein, and antibodies against C3G have been shown to detect a protein of 130-140 kDa. The carboxyl terminus of C3G ...[more]