Overexpression of DHX32 contributes to the growth and metastasis of colorectal cancer.
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ABSTRACT:
SUBMITTER: Lin H
PROVIDER: S-EPMC4363870 | biostudies-other | 2015 Mar
REPOSITORIES: biostudies-other
Publications
Overexpression of DHX32 contributes to the growth and metastasis of colorectal cancer.
Lin Huayue H Liu Wenjuan W Fang Zanxi Z Liang Xianming X Li Juan J Bai Yongying Y Lin Lingqing L You Hanyu H Pei Yihua Y Wang Fen F Zhang Zhong-Ying ZY
Scientific reports 20150318
Our previous work demonstrates that DHX32 is upregulated in colorectal cancer (CRC) compared to its adjacent normal tissues. However, how overexpressed DHX32 contributes to CRC remains largely unknown. In this study, we reported that DHX32 was overexpressed in human colon cancer cells. Overexpressed DHX32 promoted SW480 cancer cells proliferation, migration, and invasion, as well as decreased the susceptibility to chemotherapy agent 5-Fluorouracil. Furthermore, PCR array analyses revealed that d ...[more]
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