Ontology highlight
ABSTRACT:
SUBMITTER: Ricciardi M
PROVIDER: S-EPMC4366889 | biostudies-other | 2015 Mar
REPOSITORIES: biostudies-other
Ricciardi M M Zanotto M M Malpeli G G Bassi G G Perbellini O O Chilosi M M Bifari F F Krampera M M
British journal of cancer 20150317 6
<h4>Background</h4>Epithelial-to-mesenchymal transition (EMT) has a central role in cancer progression and metastatic dissemination and may be induced by local inflammation. We asked whether the inflammation-induced acquisition of mesenchymal phenotype by neoplastic epithelial cells is associated with the onset of mesenchymal stromal cell-like immune-regulatory properties that may enhance tumour immune escape.<h4>Methods</h4>Cell lines of lung adenocarcinoma (A549), breast cancer (MCF7) and hepa ...[more]