Ontology highlight
ABSTRACT:
SUBMITTER: Bajwa A
PROVIDER: S-EPMC4378101 | biostudies-other | 2015 Apr
REPOSITORIES: biostudies-other
Bajwa Amandeep A Rosin Diane L DL Chroscicki Piotr P Lee Sangju S Dondeti Krishna K Ye Hong H Kinsey Gilbert R GR Stevens Brian K BK Jobin Katarzyna K Kenwood Brandon M BM Hoehn Kyle L KL Lynch Kevin R KR Okusa Mark D MD
Journal of the American Society of Nephrology : JASN 20140821 4
Sphingosine 1-phosphate (S1P), the natural sphingolipid ligand for a family of five G protein- coupled receptors (S1P1-S1P5Rs), regulates cell survival and lymphocyte circulation. We have shown that the pan-S1PR agonist, FTY720, attenuates kidney ischemia-reperfusion injury by directly activating S1P1 on proximal tubule (PT) cells, independent of the canonical lymphopenic effects of S1P1 activation on B and T cells. FTY720 also reduces cisplatin-induced AKI. Therefore, in this study, we used con ...[more]