Ontology highlight
ABSTRACT:
SUBMITTER: Colombano G
PROVIDER: S-EPMC4384654 | biostudies-other | 2015 Feb
REPOSITORIES: biostudies-other
Colombano Giampiero G Albani Clara C Ottonello Giuliana G Ribeiro Alison A Scarpelli Rita R Tarozzo Glauco G Daglian Jennifer J Jung Kwang-Mook KM Piomelli Daniele D Bandiera Tiziano T
ChemMedChem 20141022 2
Inhibition of fatty acid amide hydrolase (FAAH) activity is under investigation as a valuable strategy for the treatment of several disorders, including pain and drug addiction. A number of potent FAAH inhibitors belonging to different chemical classes have been disclosed to date; O-aryl carbamates are one of the most representative families. In the search for novel FAAH inhibitors, a series of O-(1,2,3-triazol-4-yl)methyl carbamate derivatives were designed and synthesized exploiting a copper- ...[more]