Unknown

Dataset Information

0

A novel view of the adult bone marrow stem cell hierarchy and stem cell trafficking.


ABSTRACT: This review presents a novel view and working hypothesis about the hierarchy within the adult bone marrow stem cell compartment and the still-intriguing question of whether adult bone marrow contains primitive stem cells from early embryonic development, such as cells derived from the epiblast, migrating primordial germ cells or yolk sac-derived hemangioblasts. It also presents a novel view of the mechanisms that govern stem cell mobilization and homing, with special emphasis on the role of the complement cascade as a trigger for egress of hematopoietic stem cells from bone marrow into blood as well as the emerging role of novel homing factors and priming mechanisms that support stromal-derived factor 1-mediated homing of hematopoietic stem/progenitor cells after transplantation.

SUBMITTER: Ratajczak MZ 

PROVIDER: S-EPMC4396402 | biostudies-other | 2015 Apr

REPOSITORIES: biostudies-other

Similar Datasets

| S-EPMC6597218 | biostudies-literature
| S-EPMC3136724 | biostudies-literature
| S-EPMC2064114 | biostudies-literature
| S-EPMC8209553 | biostudies-literature
| S-EPMC7028867 | biostudies-literature
| S-EPMC2943933 | biostudies-literature
| S-EPMC1265814 | biostudies-other
| S-EPMC3327761 | biostudies-literature
| S-EPMC4704383 | biostudies-literature
| S-EPMC3056470 | biostudies-other