Ontology highlight
ABSTRACT:
SUBMITTER: Chu YW
PROVIDER: S-EPMC441480 | biostudies-other | 1995 Mar
REPOSITORIES: biostudies-other
Chu Y W YW Marin E E Fuleihan R R Ramesh N N Rosen F S FS Geha R S RS Insel R A RA
The Journal of clinical investigation 19950301 3
Somatic mutation of Ig variable regions occurs prominently in germinal centers, but it has been debated whether the mutation process initiates in germinal centers or is activated before germinal center entry of B cells. We have analyzed for the presence of somatic mutation in Ig gene rearrangements of the nonpolymorphic human VH6 gene in the X-linked HyperIgM syndrome, which is associated with defective CD40 ligand expression and absence of germinal centers and generation of memory B lymphocytes ...[more]