Ontology highlight
ABSTRACT:
SUBMITTER: Dupnik KM
PROVIDER: S-EPMC4425823 | biostudies-other | 2015 May
REPOSITORIES: biostudies-other
Dupnik Kathryn M KM Bair Thomas B TB Maia Andressa O AO Amorim Francianne M FM Costa Marcos R MR Keesen Tatjana S L TS Valverde Joanna G JG Queiroz Maria do Carmo A P Mdo C Medeiros Lúcio L LL de Lucena Nelly L NL Wilson Mary E ME Nobre Mauricio L ML Johnson Warren D WD Jeronimo Selma M B SM
The Journal of infectious diseases 20141114 10
<h4>Background</h4>Leprosy morbidity is increased by 2 pathologic immune reactions, reversal reaction (RR) and erythema nodosum leprosum (ENL).<h4>Methods</h4>To discover host factors related to immune reactions, global transcriptional profiles of peripheral blood mononuclear cells were compared between 11 RR, 11 ENL, and 19 matched control patients, with confirmation by quantitative polymerase chain reaction. Encoded proteins were investigated in skin biopsy specimens by means of immunohistoche ...[more]