Genetic modifiers and oligogenic inheritance.
Ontology highlight
ABSTRACT:
SUBMITTER: Kousi M
PROVIDER: S-EPMC4448705 | biostudies-other | 2015 Jun
REPOSITORIES: biostudies-other
Publications
Genetic modifiers and oligogenic inheritance.
Kousi Maria M Katsanis Nicholas N
Cold Spring Harbor perspectives in medicine 20150601 6
Despite remarkable progress in the identification of mutations that drive genetic disorders, progress in understanding the effect of genetic background on the penetrance and expressivity of causal alleles has been modest, in part because of the methodological challenges in identifying genetic modifiers. Nonetheless, the progressive discovery of modifier alleles has improved both our interpretative ability and our analytical tools to dissect such phenomena. In this review, we analyze the genetic ...[more]
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