Ontology highlight
ABSTRACT:
SUBMITTER: Chura-Chambi RM
PROVIDER: S-EPMC4454297 | biostudies-other | 2014
REPOSITORIES: biostudies-other
Chura-Chambi R M RM Bellini M H MH Jacysyn J F JF Andrade L N LN Medina L P LP Prieto-da-Silva A R B AR Amarante-Mendes G P GP Morganti L L
Cell death & disease 20140814
Endostatin (ES) inhibits angiogenesis, reducing tumor growth in animal models. However, it has low therapeutic effect in human clinical trials. BAX is a member of the BCL-2 family of proteins; its proapoptotic (BH3) domain interacts with other members of the family in the cytoplasm, to induce apoptosis. Here, we fused the BAX BH3 domain with murine ES, to enhance ES potency. Endothelial cells specifically internalize the fusion protein ES-BAX. The presence of the BAX domain enhances endothelial ...[more]