Ontology highlight
ABSTRACT:
SUBMITTER: Wuts PG
PROVIDER: S-EPMC4468416 | biostudies-other | 2015 Jun
REPOSITORIES: biostudies-other
Wuts Peter G M PG Simons Lloyd J LJ Metzger Brian P BP Sterling Rachel C RC Slightom Jerry L JL Elhammer Ake P AP
ACS medicinal chemistry letters 20150423 6
The natural product aureobasidin A (AbA) is a potent, well-tolerated antifungal agent with robust efficacy in animals. Although native AbA is active against a number of fungi, it has little activity against Aspergillus fumigatus, an important human pathogen, and attempts to improve the activity against this organism by structural modifications have to date involved chemistries too complex for continued development. This report describes novel chemistry for the modification of AbA. The key step i ...[more]