Ontology highlight
ABSTRACT:
SUBMITTER: Tan CW
PROVIDER: S-EPMC4471889 | biostudies-other | 2015
REPOSITORIES: biostudies-other
Tan Chin Wee CW Hirokawa Yumiko Y Burgess Antony W AW
Scientific reports 20150618
Many systems biology studies lack context-relevant data and as a consequence the predictive capabilities can be limited in developing targeted cancer therapeutics. Production of colon crypt in vitro is ideal for studying colon systems biology. This report presents the first production of, to our knowledge, physiologically-shaped, functional colon crypts in vitro (i.e. single crypts with cells expressing Mucin 2 and Chromogranin A). Time-lapsed monitoring of crypt formation revealed an increased ...[more]