Ontology highlight
ABSTRACT:
SUBMITTER: Xie F
PROVIDER: S-EPMC4493896 | biostudies-other | 2015 Jun
REPOSITORIES: biostudies-other
Xie Fuchun F Li Bingbing X BX Kassenbrock Alina A Xue Changhui C Wang Xiaoyan X Qian David Z DZ Sears Rosalie C RC Xiao Xiangshu X
Journal of medicinal chemistry 20150605 12
Recent studies have shown that nuclear transcription factor cyclic adenosine monophosphate response element binding protein (CREB) is overexpressed in many different types of cancers. Therefore, CREB has been pursued as a novel cancer therapeutic target. Naphthol AS-E and its closely related derivatives have been shown to inhibit CREB-mediated gene transcription and cancer cell growth. Previously, we identified naphthamide 3a as a different chemotype to inhibit CREB's transcription activity. In ...[more]