Matrix metalloproteinase-9 polymorphism 1562 C > T (rs3918242) associated with protection against placental malaria.
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ABSTRACT:
SUBMITTER: Apoorv TS
PROVIDER: S-EPMC4497894 | biostudies-other | 2015 Jul
REPOSITORIES: biostudies-other
Publications
Matrix metalloproteinase-9 polymorphism 1562 C > T (rs3918242) associated with protection against placental malaria.
Apoorv Thittayil Suresh TS Babu Phanithi Prakash PP Meese Stefanie S Gai Prabhanjan P PP Bedu-Addo George G Mockenhaupt Frank P FP
The American journal of tropical medicine and hygiene 20150526 1
Phagocytosis of malaria pigment (hemozoin) induces increased activity of matrix metalloproteinase (MMP)-9, an endopeptidase involved in cytokine regulation. In this study, we examined whether a common functional MMP-9 promoter polymorphism (rs3918242) affects Plasmodium falciparum infection in pregnancy. Eighteen percent of Ghanaian primiparae carried the minor T allele. It was associated with reduced odds of placental hemozoin and of placental as well as peripheral blood parasitemia. The result ...[more]
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