Ontology highlight
ABSTRACT:
SUBMITTER: Duckett CS
PROVIDER: S-EPMC450204 | biostudies-other | 1996 Jun
REPOSITORIES: biostudies-other
Duckett C S CS Nava V E VE Gedrich R W RW Clem R J RJ Van Dongen J L JL Gilfillan M C MC Shiels H H Hardwick J M JM Thompson C B CB
The EMBO journal 19960601 11
The baculovirus inhibitor of apoptosis gene, iap, can impede cell death in insect cells. Here we show that iap can also prevent cell death in mammalian cells. The ability of iap to regulate programmed cell death in widely divergent species raised the possibility that cellular homologs of iap might exist. Consistent with this hypothesis, we have isolated Drosophila and human genes which encode IAP-like proteins (dILP and hILP). Like IAP, both dILP and hILP contain amino-terminal baculovirus IAP r ...[more]