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The discovery and development of a novel vaccine to protect against Neisseria meningitidis Serogroup B Disease.


ABSTRACT: Vaccines have had a major impact on the reduction of many diseases globally. Vaccines targeted against invasive meningococcal disease (IMD) due to serogroups A, C, W, and Y are used to prevent these diseases. Until recently no vaccine had been identified that could confer broad protection against Neisseria meningitidis serogroup B (MnB). MnB causes IMD in the very young, adolescents and young adults and thus represents a significant unmet medical need. In this brief review, we describe the discovery and development of a vaccine that has the potential for broad protection against this devastating disease.

SUBMITTER: Zlotnick GW 

PROVIDER: S-EPMC4514153 | biostudies-other | 2015

REPOSITORIES: biostudies-other

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