Ontology highlight
ABSTRACT:
SUBMITTER: Ejtehadifar M
PROVIDER: S-EPMC4517092 | biostudies-other | 2015 Jun
REPOSITORIES: biostudies-other
Advanced pharmaceutical bulletin 20150601 2
Although physiological and pathological role of hypoxia have been appreciated in mammalians for decades however the cellular biology of hypoxia more clarified in the past 20 years. Discovery of the transcription factor hypoxia-inducible factor (HIF)-1, in the 1990s opened a new window to investigate the mechanisms behind hypoxia. In different cellular contexts HIF-1 activation show variable results by impacting various aspects of cell biology such as cell cycle, apoptosis, differentiation and et ...[more]