Unknown

Dataset Information

0

Insular neural system controls decision-making in healthy and methamphetamine-treated rats.


ABSTRACT: Patients suffering from neuropsychiatric disorders such as substance-related and addictive disorders exhibit altered decision-making patterns, which may be associated with their behavioral abnormalities. However, the neuronal mechanisms underlying such impairments are largely unknown. Using a gambling test, we demonstrated that methamphetamine (METH)-treated rats chose a high-risk/high-reward option more frequently and assigned higher value to high returns than control rats, suggestive of changes in decision-making choice strategy. Immunohistochemical analysis following the gambling test revealed aberrant activation of the insular cortex (INS) and nucleus accumbens in METH-treated animals. Pharmacological studies, together with in vivo microdialysis, showed that the insular neural system played a crucial role in decision-making. Moreover, manipulation of INS activation using designer receptor exclusively activated by designer drug technology resulted in alterations to decision-making. Our findings suggest that the INS is a critical region involved in decision-making and that insular neural dysfunction results in risk-taking behaviors associated with altered decision-making.

SUBMITTER: Mizoguchi H 

PROVIDER: S-EPMC4517258 | biostudies-other | 2015 Jul

REPOSITORIES: biostudies-other

Similar Datasets

| S-EPMC5809784 | biostudies-other
| S-EPMC5933819 | biostudies-literature
| S-EPMC4409560 | biostudies-other
| S-EPMC2367692 | biostudies-literature
2004-09-30 | GSE1711 | GEO
| S-EPMC7367818 | biostudies-literature
| S-EPMC4300249 | biostudies-literature
| S-EPMC4350402 | biostudies-literature
2004-09-30 | E-GEOD-1711 | biostudies-arrayexpress
| S-EPMC1809980 | biostudies-literature