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Striatum from rats treated with methamphetamine

ABSTRACT: Comparison of striatum from rats treated with either saline or 40mg/kg methamphetamine Keywords: other

ORGANISM(S): Rattus norvegicus

PROVIDER: GSE1711 | GEO | 2004/09/30

SECONDARY ACCESSION(S): PRJNA90367

REPOSITORIES: GEO

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Striatum from rats treated with methamphetamine

Project description:Comparison of striatum from rats treated with either saline or 40mg/kg methamphetamine Keywords: other

2004-09-30 | E-GEOD-1711 | biostudies-arrayexpress

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Project description:Drug abuse is a major concern with few therapeutic options. Heparan sulfate (HS) and chondroitin sulfate (CS) interact with a plethora of growth factors and their receptors, and have profound effects on cellular signaling. Thus, targeting these dynamic interactions represents a novel therapeutic modality. Our previous studies have indicated increased HS proteoglycan syndecan-3 and identified HS as a resilience factor for cocaine abuse. Here, we utilized mass spectrometry-based glycomics and proteomics to understand the effects of cocaine (C) and methamphetamine (M) on HS, CS, and proteins from two brain regions: lateral hypothalamus (LH) and striatum (ST) from mice. We observed significant differences in HS and CS total abundances and percent sulfate contents and reduction in CS 4-O-sulfation, and increase in CS 6-O-sulfation for drug-treated (C and M) vs. saline samples. The proteomics data revealed a number of aberrant proteins in drug-treated vs. saline samples, including MYPR, KCC2A, SYN2, TENR, CALX, ANXA7, HDGF, NCAN, and CSPG5, and oxidative phosphorylation among the top perturbed pathway. Taken together, our study shows for the first time the novel relationship of HS, CS, and associated proteins with the drug abuse, and shed light on, the underlying neurobiological mechanism of drug dependence and novel therapeutic options.

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