Ontology highlight
ABSTRACT:
SUBMITTER: Shi Y
PROVIDER: S-EPMC4518314 | biostudies-other | 2015 Jul
REPOSITORIES: biostudies-other
Shi Yuheng Y Yuan Bofeng B Qi Nan N Zhu Wenting W Su Jingru J Li Xiaoyan X Qi Peipei P Zhang Dan D Hou Fajian F
Nature communications 20150717
In response to virus infection, RIG-I senses viral RNA and activates the adaptor protein MAVS, which then forms prion-like filaments and stimulates a specific signalling pathway leading to type I interferon production to restrict virus proliferation. However, the mechanisms by which MAVS activity is regulated remain elusive. Here we identify distinct regions of MAVS responsible for activation of transcription factors interferon regulatory factor 3 (IRF3) and nuclear factor kappa-light-chain-enha ...[more]