Ontology highlight
ABSTRACT:
SUBMITTER: Huang H
PROVIDER: S-EPMC6082648 | biostudies-literature | 2018 Aug
REPOSITORIES: biostudies-literature
Huang Hongjun H Xiong Qingqing Q Wang Ning N Chen Ruoyu R Ren Hua H Siwko Stefan S Han Honghui H Liu Mingyao M Qian Min M Du Bing B
Science advances 20180808 8
G protein-coupled receptor 54 (GPR54), the key receptor for the neuropeptide hormone kisspeptin, plays essential roles in regulating puberty development and cancer metastasis. However, its role in the antiviral innate immune response is unknown. We report that virus-induced type I interferon (IFN-I) production was significantly enhanced in <i>Gpr54</i>-deficient cells and mice and resulted in restricted viral replication. We found a marked increase of kisspeptin in mouse serum during viral infec ...[more]