Ontology highlight
ABSTRACT:
SUBMITTER: Heilig JS
PROVIDER: S-EPMC452721 | biostudies-other | 1991 Apr
REPOSITORIES: biostudies-other
Heilig J S JS Freeman M M Laverty T T Lee K J KJ Campos A R AR Rubin G M GM Steller H H
The EMBO journal 19910401 4
Mutations in the disco (disconnected) gene prevent the establishment of stable connections between the larval optic nerves, the Bolwig's nerves, and their target cells in the brain during embryonic development. The failure of this initial connection is associated with aberrant development of the optic lobes which are largely degenerate in the mutant adult fly. In order to understand the role of disco in establishing this connection, we isolated and characterized the disco gene. A 22 kb DNA fragm ...[more]