Ontology highlight
ABSTRACT:
SUBMITTER: Liu TT
PROVIDER: S-EPMC4533715 | biostudies-other | 2015 Sep
REPOSITORIES: biostudies-other
Liu Ting-Ting TT Zeng K E KE Wang Lin L Liu Ting T Niu Ting T
Oncology letters 20150630 3
The involvement of the central nervous system (CNS) is rare in acute promyelocytic leukemia (APL). The present study reported the case of a 34-year-old male patient with APL that possessed a rare point mutation (p.Asn841Gly, c.2523C>A) in the tyrosine kinase domain of the FMS-like tyrosine kinase 3 (<i>FLT3</i>) gene and a novel Wilm tumor gene mutation (c.1209_1210insT/p.K404X). The patient suffered central nervous system and systemic relapses twice during systemic and intrathecal chemotherapy. ...[more]