Ontology highlight
ABSTRACT:
SUBMITTER: Adham N
PROVIDER: S-EPMC45671 | biostudies-other | 1993 Jan
REPOSITORIES: biostudies-other
Adham N N Kao H T HT Schecter L E LE Bard J J Olsen M M Urquhart D D Durkin M M Hartig P R PR Weinshank R L RL Branchek T A TA
Proceedings of the National Academy of Sciences of the United States of America 19930101 2
An intronless gene encoding an additional human serotonin (5-HT) 5-HT1-like receptor subtype was isolated from a human genomic library with probes obtained from degenerate PCR primers used to amplify 5-HT-receptor-specific sequences. The highest degree of homology was found with the 5-HT1E subtype (70%) and the 5-HT1D alpha (63%) and 5-HT1D beta (60%) receptors. RNA for this gene was detected in the human brain but was not detected in kidney, liver, spleen, heart, pancreas, and testes. High-affi ...[more]