Ontology highlight
ABSTRACT:
SUBMITTER: Morgner J
PROVIDER: S-EPMC4569844 | biostudies-other | 2015 Sep
REPOSITORIES: biostudies-other
Morgner Jessica J Ghatak Sushmita S Jakobi Tobias T Dieterich Christoph C Aumailley Monique M Wickström Sara A SA
Nature communications 20150908
Stem cells reside in specialized niches that are critical for their function. Quiescent hair follicle stem cells (HFSCs) are confined within the bulge niche, but how the molecular composition of the niche regulates stem cell behaviour is poorly understood. Here we show that integrin-linked kinase (ILK) is a key regulator of the bulge extracellular matrix microenvironment, thereby governing the activation and maintenance of HFSCs. ILK mediates deposition of inverse laminin (LN)-332 and LN-511 gra ...[more]