Ontology highlight
ABSTRACT:
SUBMITTER: Muchalski H
PROVIDER: S-EPMC4578693 | biostudies-other | 2015 Jan
REPOSITORIES: biostudies-other
Muchalski H H Xu L L Porter N A NA
Organic & biomolecular chemistry 20141201 4
The peroxidation of 7-dehydrocholesterol (7-DHC), a biosynthetic precursor to vitamin D3 and cholesterol, has been linked to the pathophysiology of Smith-Lemli-Optiz syndrome (SLOS), a devastating human disorder. In SLOS, 7-DHC plasma and tissue levels are elevated because of defects in the enzyme that convert it to cholesterol. α-Tocopherol can mediate the peroxidation of 7-DHC under certain circumstances and this prompted us to investigate the kinetic isotope effect (KIE) during this process. ...[more]