Unknown

Dataset Information

0

Tissue resident regulatory T cells: novel therapeutic targets for human disease.


ABSTRACT: Over the past decade, the ability of regulatory T cells (Tregs) to suppress multiple types of immune cells has received tremendous attention. Mounting evidence has revealed that tissue resident Tregs control non-immunological processes of their target tissues and contribute to a plethora of human diseases. The identification of novel tissue-specific Tregs has highlighted their heterogeneity and complexity. This review summarizes the recent findings for visceral adipose tissue CD4+Foxp3+ regulatory T cells (VAT Tregs), muscle Tregs, bone Tregs and skin memory Tregs, with a focus on their unique functions in local tissues. This interpretation of the roles of tissue-specific Tregs and of their involvement in disease progression provides new insight into the discovery of potential therapeutic targets of human diseases.

SUBMITTER: Zhou X 

PROVIDER: S-EPMC4579654 | biostudies-other | 2015 Sep

REPOSITORIES: biostudies-other

Similar Datasets

| S-EPMC6281418 | biostudies-literature
| S-EPMC5610156 | biostudies-literature
| S-EPMC3086064 | biostudies-other
| S-EPMC7050044 | biostudies-literature
| S-EPMC6214977 | biostudies-literature
| S-EPMC5366884 | biostudies-literature
| S-EPMC9005529 | biostudies-literature
| S-EPMC8666813 | biostudies-literature
| S-EPMC6668505 | biostudies-literature
| S-EPMC5818732 | biostudies-literature