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Clinical Characteristics and Features of Frequent Idiopathic Ventricular Premature Complexes in the Korean Population.

ABSTRACT: BACKGROUND AND OBJECTIVES: Frequent ventricular premature complexes (VPCs) increase the risk of cardiomyopathy (CMP). However, most data regarding VPCs have been obtained from Western population and in-hospital patient-based studies. The objective of this study was to define the clinical characteristics and features of idiopathic VPCs in the Korean population. SUBJECTS AND METHODS: We investigated subjects undergoing transthoracic echocardiography and documented VPC burdens >1% by Holter monitoring in an outpatient clinic at Samsung Medical Center, Korea. We analyzed demographic and clinical features and the nature of the VPCs by electrocardiography (ECG). RESULTS: A total of 666 patients were registered. Mean age was 54.7±16.8 years, and 365 (54.8%) patients were female. Typical VPC-related symptoms, such as palpitation and a dropped beat, were observed in 394 (59.2%) patients. Some patients received beta-blockers (n=95; 14.3%) and anti-arrhythmic agents (n=14; 2.1%). The ECG analysis was performed in 405 patients; 322 (79.5%) exhibited left bundle branch block (LBBB) and 347 (85.8%) exhibited an inferior axis. The precordial R-wave transition was predominantly distributed over V3 in 230 patients (56.6%). Thirty-one patients (4.5%) were diagnosed with VPC-induced CMP. CONCLUSION: The incidence of frequent VPCs was slightly higher in females, and palpitation was the most frequent complaint. The most common ECG features were LBBB, inferior axis, and late precordial R-wave transition.

SUBMITTER: Hwang JK

PROVIDER: S-EPMC4580698 | biostudies-other | 2015 Sep

REPOSITORIES: biostudies-other

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Clinical Characteristics and Features of Frequent Idiopathic Ventricular Premature Complexes in the Korean Population.

Hwang Jin Kyung JK Park Seung-Jung SJ On Young Keun YK Kim June Soo JS Park Kyoung-Min KM

Korean circulation journal 20150820 5

<h4>Background and objectives</h4>Frequent ventricular premature complexes (VPCs) increase the risk of cardiomyopathy (CMP). However, most data regarding VPCs have been obtained from Western population and in-hospital patient-based studies. The objective of this study was to define the clinical characteristics and features of idiopathic VPCs in the Korean population.<h4>Subjects and methods</h4>We investigated subjects undergoing transthoracic echocardiography and documented VPC burdens >1% by H ...[more]

PMID: 26413107

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Project description:Pharmacological therapy for congestive heart failure (CHF) with ventricular arrhythmia is limited. In the study, our aim was to evaluate the effects of Chinese traditional medicine Shensong Yangxin capsules (SSYX) on heart rhythm and function in CHF patients with frequent ventricular premature complexes (VPCs).This double-blind, placebo-controlled, multicenter study randomized 465 CHF patients with frequent VPCs to the SSYX (n = 232) and placebo groups (n = 233) for 12 weeks of treatment. The primary endpoint was the VPCs monitored by a 24-h ambulatory electrocardiogram. The secondary endpoints included the left ventricular ejection fraction (LVEF), left ventricular end-diastolic diameter, N-terminal pro-brain natriuretic peptide (NT-proBNP), New York Heart Association (NYHA) classification, 6-min walking distance (6MWD), Minnesota Living with Heart Failure Questionnaire (MLHFQ) scores, and composite cardiac events (CCEs).The clinical characteristics were similar at baseline. SSYX caused a significantly greater decline in the total number of VPCs than the placebo did (-2145 ± 2848 vs. -841 ± 3411, P < 0.05). The secondary endpoints of the LVEF, NYHA classification, NT-proBNP, 6MWD, and MLHFQ scores showed a greater improvements in the SSYX group than in the placebo group (?LVEF at 12th week: 4.75 ± 7.13 vs. 3.30 ± 6.53; NYHA improvement rate at the 8th and 12th week: 32.6% vs. 21.8%, 40.5% vs. 25.7%; mean level of NT-proBNP in patients with NT-proBNP ?125 pg/ml at 12th week: -122 [Q1, Q3: -524, 0] vs. -75 [Q1, Q3: -245, 0]; ?6MWD at 12th week: 35.1 ± 38.6 vs. 17.2 ± 45.6; ?MLHFQ at the 4th, 8th, and 12th week: -4.24 ± 6.15 vs. -2.31 ± 6.96, -8.19 ± 8.41 vs. -3.25 ± 9.40, -10.60 ± 9.41 vs. -4.83 ± 11.23, all P < 0.05). CCEs were not different between the groups during the study period.In this 12-week pilot study, SSYX was demonstrated to have the benefits of VPCs suppression and cardiac function improvement with good compliance on a background of standard treatment for CHF.www.chictr.org.cn, ChiCTR-TRC-12002061 (http://www.chictr.org.cn/showproj.aspx?proj=7487) and Clinicaltrials.gov, NCT01612260 (https://clinicaltrials.gov/ct2/show/NCT01612260).

Dataset Information

Clinical Characteristics and Features of Frequent Idiopathic Ventricular Premature Complexes in the Korean Population.

Publications

Clinical Characteristics and Features of Frequent Idiopathic Ventricular Premature Complexes in the Korean Population.

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