Ontology highlight
ABSTRACT:
SUBMITTER: Echbarthi M
PROVIDER: S-EPMC4607657 | biostudies-other | 2015 Nov
REPOSITORIES: biostudies-other
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The T cell costimulatory molecule TIM-1 (T cell/transmembrane, mucin and immunoglobulin domain protein 1) sorts mainly to endosomes in lymphoid cells. At difference from the cell surface protein, endosomal TIM-1 translocates to the immune synapse (IS), where it can contribute to antigen-dependent T cell costimulation. TIM-1 ligands increase the amount of cell surface protein, preventing its traffic to the IS. The bipolar sorting of TIM-1 observed during IS formation is determined by differences ...[more]