Ontology highlight
ABSTRACT:
SUBMITTER: Gaume X
PROVIDER: S-EPMC4614815 | biostudies-other | 2015
REPOSITORIES: biostudies-other
Gaume Xavier X Tassin Anne-Marie AM Ugrinova Iva I Mongelard Fabien F Monier Karine K Bouvet Philippe P
Cell cycle (Georgetown, Tex.) 20150101 6
Nucleolin is a pleiotropic protein involved in a variety of cellular processes. Although multipolar spindle formation has been observed after nucleolin depletion, the roles of nucleolin in centrosome regulation and functions have not been addressed. Here we report using immunofluorescence and biochemically purified centrosomes that nucleolin co-localized only with one of the centrioles during interphase which was further identified as the mature centriole. Upon nucleolin depletion, cells exhibit ...[more]