Dataset Information

RNAa in action: from the exception to the norm.

ABSTRACT: Small RNA programmed Argonautes are sophisticated cellular effector platforms known to be involved in a diverse array of functions ranging from mRNA cleavage, translational inhibition, DNA elimination, epigenetic silencing, alternative splicing and even gene activation. First observed in human cells, small RNA-induced gene activation, also known as RNAa, involves the targeted recruitment of Argonaute proteins to specific promoter sequences followed by induction of stable epigenetic changes which promote transcription. The existence of RNAa remains contentious due to its elusive mechanism. A string of recent studies in C. elegans provides unequivocal evidence for RNAa's fundamental role in sculpting the epigenetic landscape and maintaining active transcription of endogenous genes and supports the presence of a functionally sophisticated network of small RNA-Argonaute pathways consisting of opposite yet complementary "yin and yang" regulatory elements. In this review, we summarize key findings from recent studies of endogenous RNAa in C. elegans, with an emphasis on the Argonaute protein CSR-1.

SUBMITTER: Guo D

PROVIDER: S-EPMC4615537 | biostudies-other | 2014

REPOSITORIES: biostudies-other

ACCESS DATA

Similar Datasets

Project description:IntroductionIn times of rising energy prices and increasing importance of climate change, saving energy becomes even more important. Universities are large public institutions with significant energy-saving potential. This study investigated the energy-saving behavior of students and employees at a German university. In contrast to previous studies, which often focused on individual buildings, this study took a comprehensive approach and addressed all university members (employees and students). A extended model of the Theory of Planned Behavior (TPB) served as the theoretical basis. Considering the specific organizational context, the main question of the study was to explore the interlinkages between the intention to save energy, corresponding consumption behavior, and the effects of injunctive and descriptive social norms within the social system of the organization. Furthermore, the impact of "not energy related" factors like the identification with the organization was tested.MethodsAs methodological approach a university-wide quantitative online survey was conducted. For the survey, a standardized questionnaire containing several scales on energy consumption behavior and TBP-constructs was used. All in all, data from a total of 1,714 members of the university participating in the study was analyzed.ResultsStructural equation modeling showed that the extended TPB model yields a satisfactory amount of explained variance (approximately 40%) for intention and a moderate amount (approximately 20%) for behavior. The strongest predictors are personal norm and behavioral control. The organizational influence factor identification was also significant for intention, but only to a small extent.DiscussionThe results extend the understanding of the TPB in the context of energy conservation in universities and emphasize that the sense of behavioral control and the personal norm must always be considered when intervening in this context to promote energy conservation and thus provide valuable hints for practical measures.

Dataset Information

RNAa in action: from the exception to the norm.

Similar Datasets

OmicsDI is part of the ELIXIR infrastructure

Tweets