Ontology highlight
ABSTRACT:
SUBMITTER: Payne JL
PROVIDER: S-EPMC4621482 | biostudies-other | 2015
REPOSITORIES: biostudies-other
Payne Joshua L JL Wagner Andreas A
Frontiers in genetics 20151027
Robustness is the invariance of a phenotype in the face of environmental or genetic change. The phenotypes produced by transcriptional regulatory circuits are gene expression patterns that are to some extent robust to mutations. Here we review several causes of this robustness. They include robustness of individual transcription factor binding sites, homotypic clusters of such sites, redundant enhancers, transcription factors, redundant transcription factors, and the wiring of transcriptional re ...[more]